GLP-1.apphttps://glp-1.app/GLP-1 research, explained.enWhat happens when you stop a GLP-1? What three trials found about weight regainhttps://glp-1.app/stopping-glp-1-weight-regain/https://glp-1.app/stopping-glp-1-weight-regain/STEP 1, STEP 4 and SURMOUNT-4 followed people who stopped semaglutide or tirzepatide. Here is how much weight came back, how fast, and what it means.Trial resultsWed, 04 Nov 2026 00:00:00 +0000Semaglutide vs tirzepatide: which leads to more weight loss? What the head-to-head trial foundhttps://glp-1.app/semaglutide-vs-tirzepatide/https://glp-1.app/semaglutide-vs-tirzepatide/SURMOUNT-5 compared tirzepatide and semaglutide head to head for 72 weeks in 751 adults with obesity. The weight, waist and side-effect results, plus caveats.ComparisonsWed, 04 Nov 2026 00:00:00 +0000How much protein do you need on a GLP-1? What the research says about protecting musclehttps://glp-1.app/protein-on-glp-1/https://glp-1.app/protein-on-glp-1/Part of the weight lost on semaglutide and tirzepatide is lean mass. Here is what the trials measured, what the 2025 nutrition advisory suggests for protein, and a quick calculator.NutritionWed, 04 Nov 2026 00:00:00 +0000How much weight do people lose on oral semaglutide? What the OASIS trials foundhttps://glp-1.app/oral-semaglutide-weight-loss/https://glp-1.app/oral-semaglutide-weight-loss/OASIS 1 and OASIS 4 tested daily semaglutide pills for weight loss. Here is how much weight people lost, how it compares with the weekly shot, and side effects.Trial resultsWed, 04 Nov 2026 00:00:00 +0000How much weight do people lose on GLP-1 medication? What STEP 1 and SURMOUNT-1 foundhttps://glp-1.app/glp-1-weight-loss-results/https://glp-1.app/glp-1-weight-loss-results/The two landmark trials behind Wegovy and Zepbound, in plain English: average weight loss, how many people reached 10% or 20%, side effects and what the averages hide.Trial resultsWed, 04 Nov 2026 00:00:00 +0000How much weight do people with type 2 diabetes lose on a GLP-1? What STEP 2 and SURMOUNT-2 foundhttps://glp-1.app/glp-1-type-2-diabetes-weight-loss/https://glp-1.app/glp-1-type-2-diabetes-weight-loss/STEP 2 and SURMOUNT-2 tested semaglutide 2.4 mg and tirzepatide for weight loss in adults with type 2 diabetes. Here are the results and how they compare.Trial resultsWed, 04 Nov 2026 00:00:00 +0000Can tirzepatide help sleep apnea? What the SURMOUNT-OSA trials foundhttps://glp-1.app/glp-1-sleep-apnea/https://glp-1.app/glp-1-sleep-apnea/Two SURMOUNT-OSA trials tested tirzepatide in adults with obesity and moderate-to-severe sleep apnea. Here is what AHI means and how much it changed in a year.Health conditionsWed, 04 Nov 2026 00:00:00 +0000How common is nausea on a GLP-1, and how long does it last? What the research sayshttps://glp-1.app/glp-1-side-effects-nausea/https://glp-1.app/glp-1-side-effects-nausea/Nausea, diarrhea, vomiting and constipation on semaglutide and tirzepatide: how often they happened in trials, when they peaked, and what helped.Side effectsWed, 04 Nov 2026 00:00:00 +0000Does GLP-1 weight loss last? What two- and three-year trials foundhttps://glp-1.app/glp-1-long-term-results/https://glp-1.app/glp-1-long-term-results/STEP 5 followed semaglutide for two years and SURMOUNT-1 followed tirzepatide for three. Here is whether weight stayed off and what happened to diabetes risk.Trial resultsWed, 04 Nov 2026 00:00:00 +0000Does semaglutide help knee osteoarthritis pain? What the STEP 9 trial foundhttps://glp-1.app/glp-1-knee-osteoarthritis/https://glp-1.app/glp-1-knee-osteoarthritis/STEP 9 tested semaglutide in adults with obesity and painful knee osteoarthritis. Here is what happened to weight, pain and physical function over 68 weeks.Health conditionsWed, 04 Nov 2026 00:00:00 +0000Does semaglutide lower the risk of heart attack and stroke? What the SELECT trial foundhttps://glp-1.app/glp-1-heart-select-trial/https://glp-1.app/glp-1-heart-select-trial/SELECT followed 17,604 adults with heart disease and overweight or obesity but no diabetes. What semaglutide 2.4 mg did to heart attacks, strokes and weight.Health conditionsWed, 04 Nov 2026 00:00:00 +0000Does semaglutide or tirzepatide cause hair loss? What the research sayshttps://glp-1.app/glp-1-hair-loss/https://glp-1.app/glp-1-hair-loss/How often hair loss was reported in GLP-1 trials, why rapid weight loss is the leading explanation, and what is still unknown about the cause.Side effectsWed, 04 Nov 2026 00:00:00 +0000Can GLP-1 medicines help fatty liver disease (MASH)? What the trials foundhttps://glp-1.app/glp-1-fatty-liver/https://glp-1.app/glp-1-fatty-liver/Semaglutide's phase 3 ESSENCE trial and tirzepatide's phase 2 SYNERGY-NASH trial checked liver biopsies in people with MASH. Here is what changed, in plain words.Health conditionsWed, 04 Nov 2026 00:00:00 +0000